G35G (p.Gly35Gly) variant of DSP (Desmoplakin)

Name: DSP G35G (p.Gly35Gly) variant | CATVariant
Creator: Center for Precision Medicine and Data Sciences
Published: 2026-08-09
License: https://catvariant.com/terms-of-use

G35G (p.Gly35Gly) in DSP (Desmoplakin) is a synonymous change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data, published literature, and structural context.

G35G (p.Gly35Gly) variant details

p.Gly35Gly
rs77445784
gnomAD 6-7542020-G-A
Synonymous
Variant Prioritization Score for Impact Estimate 0.17
CADD 10.80
Most common in the Non-Finnish European population (allele frequency 5.8e-05)
Structural context available
Cited in: A systematic approach to assessing the clinical significance of genetic variants. (PMID 24033266)
Cited in: Arrhythmogenic right ventricular dysplasia/cardiomyopathy: pathogenic desmosome mutations in index-patients predict… (PMID 21606396)