V10M (p.Val10Met) variant of DNMT1 (P26358)
V10M (p.Val10Met) in DNMT1 (P26358) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
V10M (p.Val10Met) variant details
- p.Val10Met
- TOPMed rs1269997956
- gnomAD rs1269997956
- Missense
- Variant Prioritization Score for Impact Estimate 0.345
- REVEL 0.11
- CADD 24.80
- PolyPhen-2 1.00
- SIFT 0.08
- Most common in the HGDP:BURUSHO population (allele frequency 0.042)
- Structural context available