S84F (p.Ser84Phe) variant of DNMT1 (P26358)
S84F (p.Ser84Phe) in DNMT1 (P26358) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data and structural context.
S84F (p.Ser84Phe) variant details
- p.Ser84Phe
- NCI-TCGA Cosmic COSV6158
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.423
- REVEL 0.16
- CADD 24.90
- PolyPhen-2 0.84
- SIFT 0.12
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 0.00048)
- Structural context available