R26K (p.Arg26Lys) variant of DNMT1 (P26358)
R26K (p.Arg26Lys) in DNMT1 (P26358) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
R26K (p.Arg26Lys) variant details
- p.Arg26Lys
- TOPMed rs1340824034
- Missense
- Variant Prioritization Score for Impact Estimate 0.361
- REVEL 0.15
- CADD 23.30
- PolyPhen-2 0.98
- SIFT 0.53
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available