R25C (p.Arg25Cys) variant of DNMT1 (P26358)
R25C (p.Arg25Cys) in DNMT1 (P26358) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.57 / 1. The record also includes population frequency data and structural context.
R25C (p.Arg25Cys) variant details
- p.Arg25Cys
- gnomAD rs1206120198
- Missense
- Variant Prioritization Score for Impact Estimate 0.569
- REVEL 0.39
- CADD 32.00
- PolyPhen-2 0.97
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 0.00041)
- Structural context available