L13M (p.Leu13Met) variant of DNMT1 (P26358)
L13M (p.Leu13Met) in DNMT1 (P26358) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data and structural context.
L13M (p.Leu13Met) variant details
- p.Leu13Met
- ExAC rs762812098
- TOPMed rs762812098
- gnomAD rs762812098
- Missense
- Variant Prioritization Score for Impact Estimate 0.276
- REVEL 0.07
- CADD 22.40
- PolyPhen-2 1.00
- SIFT 0.10
- Most common in the Middle Eastern population (allele frequency 0.0007)
- Structural context available