K88E (p.Lys88Glu) variant of DNMT1 (P26358)
K88E (p.Lys88Glu) in DNMT1 (P26358) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data and structural context.
K88E (p.Lys88Glu) variant details
- p.Lys88Glu
- TOPMed rs1456240920
- gnomAD rs1456240920
- Missense
- Variant Prioritization Score for Impact Estimate 0.403
- REVEL 0.24
- CADD 24.40
- PolyPhen-2 0.99
- SIFT 0.09
- Most common in the Non-Finnish European population (allele frequency 2.9e-05)
- Structural context available