G121R (p.Gly121Arg) variant of DNMT1 (P26358)
G121R (p.Gly121Arg) in DNMT1 (P26358) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.04 / 1. The record also includes population frequency data and structural context.
G121R (p.Gly121Arg) variant details
- p.Gly121Arg
- gnomAD rs1331733943
- Missense
- Variant Prioritization Score for Impact Estimate 0.0354
- REVEL 0.01
- CADD 0.52
- PolyPhen-2 0.00
- SIFT 0.61
- Most common in the Middle Eastern population (allele frequency 0.0007)
- Structural context available