G105E (p.Gly105Glu) variant of DNMT1 (P26358)
G105E (p.Gly105Glu) in DNMT1 (P26358) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
G105E (p.Gly105Glu) variant details
- p.Gly105Glu
- cosmic curated COSV61583
- Missense
- Variant Prioritization Score for Impact Estimate 0.359
- REVEL 0.22
- CADD 24.20
- PolyPhen-2 0.81
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 0.00012)
- Structural context available