C41W (p.Cys41Trp) variant of DNMT1 (P26358)
C41W (p.Cys41Trp) in DNMT1 (P26358) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data and structural context.
C41W (p.Cys41Trp) variant details
- p.Cys41Trp
- ExAC rs779730617
- gnomAD rs779730617
- Missense
- Variant Prioritization Score for Impact Estimate 0.292
- REVEL 0.33
- CADD 22.30
- PolyPhen-2 1.00
- SIFT 0.14
- Most common in the REMAINING population (allele frequency 0.00048)
- Structural context available