W12C (p.Trp12Cys) variant of CYP3A4 (Cytochrome P450 3A4)
W12C (p.Trp12Cys) in CYP3A4 (Cytochrome P450 3A4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.66 / 1. The record also includes population frequency data.
W12C (p.Trp12Cys) variant details
- p.Trp12Cys
- gnomAD rs1178534862
- Missense
- Variant Prioritization Score for Impact Estimate 0.663
- CADD 23.30
- PolyPhen-2 1.00
- SIFT 0.01
- Most common in the South Asian population (allele frequency 2.3e-05)