T136A (p.Thr136Ala) variant of CYP3A4 (Cytochrome P450 3A4)
T136A (p.Thr136Ala) in CYP3A4 (Cytochrome P450 3A4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data.
T136A (p.Thr136Ala) variant details
- p.Thr136Ala
- ExAC rs748236460
- TOPMed rs748236460
- gnomAD rs748236460
- Missense
- Variant Prioritization Score for Impact Estimate 0.125
- CADD 8.19
- PolyPhen-2 0.01
- SIFT 0.20
- Most common in the Ashkenazi Jewish population (allele frequency 0.0023)