S134C (p.Ser134Cys) variant of CYP3A4 (Cytochrome P450 3A4)
S134C (p.Ser134Cys) in CYP3A4 (Cytochrome P450 3A4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data.
S134C (p.Ser134Cys) variant details
- p.Ser134Cys
- ESP rs376124415
- ExAC rs376124415
- TOPMed rs376124415
- gnomAD rs376124415
- Missense
- Variant Prioritization Score for Impact Estimate 0.429
- CADD 24.30
- PolyPhen-2 0.62
- SIFT 0.01
- Most common in the African/African-American population (allele frequency 4.8e-05)