R162W (p.Arg162Trp) variant of CYP3A4 (Cytochrome P450 3A4)
R162W (p.Arg162Trp) in CYP3A4 (Cytochrome P450 3A4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data.
R162W (p.Arg162Trp) variant details
- p.Arg162Trp
- 1000Genomes rs57409622
- ESP rs57409622
- ExAC rs57409622
- TOPMed rs57409622
- Missense
- Variant Prioritization Score for Impact Estimate 0.25
- AlphaMissense 0.15
- MetaLR 0.08
- MetaSVM -1.04
- CADD 22.20
- PolyPhen-2 0.36
- SIFT 0.04
- Most common in the 1KG:ACB population (allele frequency 0.011)