R106T (p.Arg106Thr) variant of CYP3A4 (Cytochrome P450 3A4)
R106T (p.Arg106Thr) in CYP3A4 (Cytochrome P450 3A4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.63 / 1. The record also includes population frequency data and structural context.
R106T (p.Arg106Thr) variant details
- p.Arg106Thr
- ExAC rs770609053
- TOPMed rs770609053
- gnomAD rs770609053
- Missense
- Variant Prioritization Score for Impact Estimate 0.625
- CADD 22.80
- PolyPhen-2 0.55
- SIFT 0.01
- Most common in the Latino/Admixed American population (allele frequency 4.5e-05)
- Structural context available