R106K (p.Arg106Lys) variant of CYP3A4 (Cytochrome P450 3A4)
R106K (p.Arg106Lys) in CYP3A4 (Cytochrome P450 3A4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.59 / 1. The record also includes population frequency data and structural context.
R106K (p.Arg106Lys) variant details
- p.Arg106Lys
- ExAC rs770609053
- TOPMed rs770609053
- gnomAD rs770609053
- Missense
- Variant Prioritization Score for Impact Estimate 0.586
- CADD 20.40
- PolyPhen-2 0.09
- SIFT 0.03
- Most common in the South Asian population (allele frequency 3.5e-05)
- Structural context available