R105W (p.Arg105Trp) variant of CYP3A4 (Cytochrome P450 3A4)
R105W (p.Arg105Trp) in CYP3A4 (Cytochrome P450 3A4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.48 / 1. The record also includes population frequency data and structural context.
R105W (p.Arg105Trp) variant details
- p.Arg105Trp
- ESP rs142296281
- ExAC rs142296281
- TOPMed rs142296281
- gnomAD rs142296281
- Missense
- Variant Prioritization Score for Impact Estimate 0.476
- CADD 24.40
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Ashkenazi Jewish population (allele frequency 3.8e-05)
- Structural context available