R105Q (p.Arg105Gln) variant of CYP3A4 (Cytochrome P450 3A4)
R105Q (p.Arg105Gln) in CYP3A4 (Cytochrome P450 3A4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.74 / 1. The record also includes population frequency data and structural context.
R105Q (p.Arg105Gln) variant details
- p.Arg105Gln
- ExAC rs774082727
- TOPMed rs774082727
- gnomAD rs774082727
- Missense
- Variant Prioritization Score for Impact Estimate 0.743
- CADD 24.50
- PolyPhen-2 0.84
- SIFT 0.01
- Most common in the Latino/Admixed American population (allele frequency 6.7e-05)
- Structural context available