R105L (p.Arg105Leu) variant of CYP3A4 (Cytochrome P450 3A4)
R105L (p.Arg105Leu) in CYP3A4 (Cytochrome P450 3A4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.75 / 1. The record also includes population frequency data and structural context.
R105L (p.Arg105Leu) variant details
- p.Arg105Leu
- ExAC rs774082727
- TOPMed rs774082727
- gnomAD rs774082727
- Missense
- Variant Prioritization Score for Impact Estimate 0.745
- CADD 24.60
- PolyPhen-2 0.98
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available