L36R (p.Leu36Arg) variant of CYP3A4 (Cytochrome P450 3A4)
L36R (p.Leu36Arg) in CYP3A4 (Cytochrome P450 3A4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.58 / 1. The record also includes population frequency data and structural context.
L36R (p.Leu36Arg) variant details
- p.Leu36Arg
- ExAC rs764141268
- gnomAD rs764141268
- Missense
- Variant Prioritization Score for Impact Estimate 0.585
- CADD 22.60
- PolyPhen-2 0.17
- SIFT 0.01
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available