L21V (p.Leu21Val) variant of CYP3A4 (Cytochrome P450 3A4)
L21V (p.Leu21Val) in CYP3A4 (Cytochrome P450 3A4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.58 / 1. The record also includes population frequency data.
L21V (p.Leu21Val) variant details
- p.Leu21Val
- ExAC rs761240600
- gnomAD rs761240600
- Missense
- Variant Prioritization Score for Impact Estimate 0.584
- CADD 23.00
- PolyPhen-2 0.84
- SIFT 0.02
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)