L172F (p.Leu172Phe) variant of CYP3A4 (Cytochrome P450 3A4)
L172F (p.Leu172Phe) in CYP3A4 (Cytochrome P450 3A4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
L172F (p.Leu172Phe) variant details
- p.Leu172Phe
- TOPMed rs1815579281
- Missense
- Variant Prioritization Score for Impact Estimate 0.337
- CADD 14.10
- PolyPhen-2 0.27
- SIFT 0.01
- Most common in the African/African-American population (allele frequency 9e-05)
- Structural context available