L15P (p.Leu15Pro) variant of CYP3A4 (Cytochrome P450 3A4)
L15P (p.Leu15Pro) in CYP3A4 (Cytochrome P450 3A4) is a missense change. Clinical records from EBI and UniProt describe it as benign in the context of in allele CYP3A4*14. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes published literature.
L15P (p.Leu15Pro) variant details
- p.Leu15Pro
- rs12721634
- UniProt VAR 011597
- Ensembl rs12721634
- Benign
- in allele CYP3A4*14
- Missense
- Variant Prioritization Score for Impact Estimate 0.329
- AlphaMissense 0.17
- MetaLR 0.05
- MetaSVM -1.14
- PolyPhen-2 0.98
- SIFT 0.01
- MutPred 0.24
- EBI: Benign (in allele CYP3A4*14)
- UniProt: Benign (in allele CYP3A4*14)
- Cited in: Common allelic variants of cytochrome P4503A4 and their prevalence in different populations. (PMID 11875366)