G77R (p.Gly77Arg) variant of CYP3A4 (Cytochrome P450 3A4)
G77R (p.Gly77Arg) in CYP3A4 (Cytochrome P450 3A4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.64 / 1. The record also includes population frequency data.
G77R (p.Gly77Arg) variant details
- p.Gly77Arg
- TOPMed rs1446253503
- gnomAD rs1446253503
- Missense
- Variant Prioritization Score for Impact Estimate 0.643
- CADD 24.60
- PolyPhen-2 0.98
- SIFT 0.02
- Most common in the Latino/Admixed American population (allele frequency 4.5e-05)