G109R (p.Gly109Arg) variant of CYP3A4 (Cytochrome P450 3A4)
G109R (p.Gly109Arg) in CYP3A4 (Cytochrome P450 3A4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.61 / 1. The record also includes population frequency data.
G109R (p.Gly109Arg) variant details
- p.Gly109Arg
- ExAC rs777024826
- TOPMed rs777024826
- gnomAD rs777024826
- Missense
- Variant Prioritization Score for Impact Estimate 0.61
- CADD 18.70
- PolyPhen-2 0.25
- SIFT 0.21
- Most common in the African/African-American population (allele frequency 4.8e-05)