F60L (p.Phe60Leu) variant of CYP3A4 (Cytochrome P450 3A4)
F60L (p.Phe60Leu) in CYP3A4 (Cytochrome P450 3A4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.58 / 1. The record also includes population frequency data and structural context.
F60L (p.Phe60Leu) variant details
- p.Phe60Leu
- ExAC rs754353680
- TOPMed rs754353680
- gnomAD rs754353680
- Missense
- Variant Prioritization Score for Impact Estimate 0.577
- CADD 22.80
- PolyPhen-2 0.42
- SIFT 0.01
- Most common in the Middle Eastern population (allele frequency 0.00035)
- Structural context available