C58R (p.Cys58Arg) variant of CYP3A4 (Cytochrome P450 3A4)
C58R (p.Cys58Arg) in CYP3A4 (Cytochrome P450 3A4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.61 / 1. The record also includes population frequency data and structural context.
C58R (p.Cys58Arg) variant details
- p.Cys58Arg
- TOPMed rs1815819162
- gnomAD rs1815819162
- Missense
- Variant Prioritization Score for Impact Estimate 0.606
- CADD 10.30
- PolyPhen-2 0.02
- SIFT 0.18
- Most common in the Latino/Admixed American population (allele frequency 4.5e-05)
- Structural context available