A121D (p.Ala121Asp) variant of CYP3A4 (Cytochrome P450 3A4)
A121D (p.Ala121Asp) in CYP3A4 (Cytochrome P450 3A4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.75 / 1. The record also includes population frequency data and structural context.
A121D (p.Ala121Asp) variant details
- p.Ala121Asp
- ExAC rs779224668
- TOPMed rs779224668
- gnomAD rs779224668
- Missense
- Variant Prioritization Score for Impact Estimate 0.754
- CADD 22.70
- PolyPhen-2 0.98
- SIFT 0.04
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available