R63W (p.Arg63Trp) variant of CRMP1 (Q14194)
R63W (p.Arg63Trp) in CRMP1 (Q14194) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.66 / 1. The record also includes population frequency data and structural context.
R63W (p.Arg63Trp) variant details
- p.Arg63Trp
- rs147608754
- ClinGen CA2837395
- cosmic curated COSV10027
- ClinVar RCV004367426
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.659
- ESM-1b 1.00
- AlphaMissense 0.20
- MetaLR 0.60
- MetaSVM 0.32
- PolyPhen-2 0.99
- SIFT 0.00
- ClinVar: Uncertain significance (not specified)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Population evidence available
- Structural context available