M73I (p.Met73Ile) variant of CALM2 (Calmodulin-2)
M73I (p.Met73Ile) in CALM2 (Calmodulin-2) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.75 / 1. The record also includes population frequency data and structural context.
M73I (p.Met73Ile) variant details
- p.Met73Ile
- NCI-TCGA Cosmic COSV9935
- cosmic curated COSV99355
- NCI-TCGA Cosmic COSV6366
- cosmic curated COSV63663
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.753
- REVEL 0.82
- MetaLR 0.54
- MetaSVM 0.11
- CADD 25.60
- PolyPhen-2 0.65
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available