T86I (p.Thr86Ile) variant of C5 (Complement C5)
T86I (p.Thr86Ile) in C5 (Complement C5) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data and structural context.
T86I (p.Thr86Ile) variant details
- p.Thr86Ile
- gnomAD rs1292060150
- Missense
- Variant Prioritization Score for Impact Estimate 0.251
- REVEL 0.11
- MetaLR 0.09
- MetaSVM -1.03
- CADD 21.40
- PolyPhen-2 0.04
- SIFT 0.04
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available