K153T (p.Lys153Thr) variant of C5 (Complement C5)
K153T (p.Lys153Thr) in C5 (Complement C5) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data and structural context.
K153T (p.Lys153Thr) variant details
- p.Lys153Thr
- gnomAD rs1289985711
- Missense
- Variant Prioritization Score for Impact Estimate 0.432
- REVEL 0.49
- MetaLR 0.50
- MetaSVM 0.04
- CADD 25.80
- PolyPhen-2 0.94
- SIFT 0.00
- Most common in the Latino/Admixed American population (allele frequency 2.3e-05)
- Structural context available