F64Y (p.Phe64Tyr) variant of C5 (Complement C5)
F64Y (p.Phe64Tyr) in C5 (Complement C5) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data and structural context.
F64Y (p.Phe64Tyr) variant details
- p.Phe64Tyr
- ExAC rs762278531
- gnomAD rs762278531
- Missense
- Variant Prioritization Score for Impact Estimate 0.152
- REVEL 0.06
- MetaLR 0.04
- MetaSVM -0.99
- CADD 11.20
- PolyPhen-2 0.09
- SIFT 0.71
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available