D151E (p.Asp151Glu) variant of C5 (Complement C5)
D151E (p.Asp151Glu) in C5 (Complement C5) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data and structural context.
D151E (p.Asp151Glu) variant details
- p.Asp151Glu
- NCI-TCGA Cosmic COSV5632
- NCI-TCGA Cosmic COSV9979
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.29
- REVEL 0.14
- MetaLR 0.10
- MetaSVM -1.01
- CADD 11.90
- PolyPhen-2 0.01
- SIFT 1.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.9e-06)
- Structural context available