G86S (p.Gly86Ser) variant of BCL11B (B-cell lymphoma/leukemia 11B)
G86S (p.Gly86Ser) in BCL11B (B-cell lymphoma/leukemia 11B) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data and structural context.
G86S (p.Gly86Ser) variant details
- p.Gly86Ser
- rs1198790814
- NCI-TCGA Cosmic COSV6173
- cosmic curated COSV61734
- gnomAD rs1198790814
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.188
- REVEL 0.06
- CADD 17.20
- PolyPhen-2 0.00
- SIFT 0.21
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Latino/Admixed American population (allele frequency 6.6e-05)
- Structural context available