G86C (p.Gly86Cys) variant of BCL11B (B-cell lymphoma/leukemia 11B)
G86C (p.Gly86Cys) in BCL11B (B-cell lymphoma/leukemia 11B) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data and structural context.
G86C (p.Gly86Cys) variant details
- p.Gly86Cys
- rs1198790814
- NCI-TCGA Cosmic COSV6173
- gnomAD rs1198790814
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.24
- REVEL 0.12
- CADD 19.50
- PolyPhen-2 0.42
- SIFT 0.17
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available