R87W (p.Arg87Trp) variant of BCL10 (B-cell lymphoma/leukemia 10)
R87W (p.Arg87Trp) in BCL10 (B-cell lymphoma/leukemia 10) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data and structural context.
R87W (p.Arg87Trp) variant details
- p.Arg87Trp
- rs949558985
- NCI-TCGA Cosmic COSV1044
- cosmic curated COSV10442
- TOPMed rs949558985
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.448
- MetaLR 0.03
- MetaSVM -1.10
- CADD 24.00
- PolyPhen-2 0.12
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the East Asian population (allele frequency 0.00019)
- Structural context available