R25C (p.Arg25Cys) variant of BCL10 (B-cell lymphoma/leukemia 10)
R25C (p.Arg25Cys) in BCL10 (B-cell lymphoma/leukemia 10) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.55 / 1. The record also includes population frequency data.
R25C (p.Arg25Cys) variant details
- p.Arg25Cys
- NCI-TCGA Cosmic COSV6535
- cosmic curated COSV65354
- Ensembl rs2100748133
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.552
- MetaLR 0.15
- MetaSVM -0.79
- CADD 26.60
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)