I86V (p.Ile86Val) variant of BCL10 (B-cell lymphoma/leukemia 10)
I86V (p.Ile86Val) in BCL10 (B-cell lymphoma/leukemia 10) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes population frequency data and structural context.
I86V (p.Ile86Val) variant details
- p.Ile86Val
- rs1346396823
- NCI-TCGA Cosmic COSV1009
- cosmic curated COSV10099
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.508
- MetaLR 0.11
- MetaSVM -0.97
- CADD 24.60
- PolyPhen-2 0.71
- SIFT 0.02
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Middle Eastern population (allele frequency 0.00017)
- Structural context available