BAX (Apoptosis regulator BAX) variants and mutations

BAX (also known as Apoptosis regulator BAX) is a human protein-coding gene encoding an apoptosis regulator protein. During intrinsic apoptosis, it oligomerizes in the mitochondrial outer membrane to release cytochrome c and activate caspases. Altered BAX activity can change cellular sensitivity to stress and anticancer therapy. This analysis covers 431 BAX variants and mutations. Of these, 94% have computational variant effect predictions. Disease context includes T-cell acute lymphoblastic leukemia, colon carcinoma, and endometrial carcinoma. Example BAX variants include D2Y, D2N, and D2G.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, 3D Hotspot Analysis, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable BAX variants

Examples include D2Y, D2N, D2G, D2E, G3R, G3W, G3*, G3V. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.