S2P (p.Ser2Pro) variant of B2M (Beta-2-microglobulin)
S2P (p.Ser2Pro) in B2M (Beta-2-microglobulin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data and structural context.
S2P (p.Ser2Pro) variant details
- p.Ser2Pro
- TOPMed rs1165361280
- gnomAD rs1165361280
- Missense
- Variant Prioritization Score for Impact Estimate 0.178
- MetaLR 0.00
- MetaSVM -0.90
- CADD 14.30
- PolyPhen-2 0.22
- SIFT 0.05
- Most common in the Middle Eastern population (allele frequency 0.00017)
- Structural context available