S14P (p.Ser14Pro) variant of B2M (Beta-2-microglobulin)
S14P (p.Ser14Pro) in B2M (Beta-2-microglobulin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.48 / 1. The record also includes population frequency data and structural context.
S14P (p.Ser14Pro) variant details
- p.Ser14Pro
- TOPMed rs956925311
- gnomAD rs956925311
- Missense
- Variant Prioritization Score for Impact Estimate 0.484
- MetaLR 0.01
- MetaSVM -0.92
- CADD 14.60
- PolyPhen-2 0.20
- SIFT 0.21
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available