L15F (p.Leu15Phe) variant of B2M (Beta-2-microglobulin)
L15F (p.Leu15Phe) in B2M (Beta-2-microglobulin) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data and structural context.
L15F (p.Leu15Phe) variant details
- p.Leu15Phe
- rs1329285364
- gnomAD rs1329285364
- NCI-TCGA Cosmic COSV6256
- cosmic curated COSV62563
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.439
- MetaLR 0.01
- MetaSVM -0.93
- CADD 16.40
- PolyPhen-2 0.09
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available