L10F (p.Leu10Phe) variant of B2M (Beta-2-microglobulin)
L10F (p.Leu10Phe) in B2M (Beta-2-microglobulin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.11 / 1. The record also includes population frequency data and structural context.
L10F (p.Leu10Phe) variant details
- p.Leu10Phe
- cosmic curated COSV62566
- ExAC rs755159854
- TOPMed rs755159854
- gnomAD rs755159854
- Missense
- Variant Prioritization Score for Impact Estimate 0.105
- MetaLR 0.01
- MetaSVM -0.94
- CADD 0.65
- PolyPhen-2 0.02
- SIFT 0.14
- Most common in the South Asian population (allele frequency 2.3e-05)
- Structural context available