W15L (p.Trp15Leu) variant of APOL1 (Apolipoprotein L1)
W15L (p.Trp15Leu) in APOL1 (Apolipoprotein L1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data, published literature, and structural context.
W15L (p.Trp15Leu) variant details
- p.Trp15Leu
- gnomAD 22-36254999-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.353
- REVEL 0.09
- MetaLR 0.07
- MetaSVM -1.05
- CADD 29.20
- PolyPhen-2 0.64
- SIFT 0.02
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available
- Literature evidence available