R26S (p.Arg26Ser) variant of APOL1 (Apolipoprotein L1)
R26S (p.Arg26Ser) in APOL1 (Apolipoprotein L1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data, published literature, and structural context.
R26S (p.Arg26Ser) variant details
- p.Arg26Ser
- gnomAD 22-36257116-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.195
- REVEL 0.12
- MetaLR 0.07
- MetaSVM -1.05
- CADD 16.60
- PolyPhen-2 0.79
- SIFT 0.02
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available