L19F (p.Leu19Phe) variant of APOL1 (Apolipoprotein L1)
L19F (p.Leu19Phe) in APOL1 (Apolipoprotein L1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data and structural context.
L19F (p.Leu19Phe) variant details
- p.Leu19Phe
- gnomAD rs202025045
- Missense
- Variant Prioritization Score for Impact Estimate 0.32
- REVEL 0.12
- CADD 15.50
- PolyPhen-2 0.97
- SIFT 0.09
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available