L12F (p.Leu12Phe) variant of APOL1 (Apolipoprotein L1)
L12F (p.Leu12Phe) in APOL1 (Apolipoprotein L1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data and structural context.
L12F (p.Leu12Phe) variant details
- p.Leu12Phe
- cosmic curated COSV10518
- Missense
- Variant Prioritization Score for Impact Estimate 0.166
- REVEL 0.08
- CADD 16.20
- PolyPhen-2 0.35
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available