T74A (p.Thr74Ala) variant of APOB (Apolipoprotein B-100)
T74A (p.Thr74Ala) in APOB (Apolipoprotein B-100) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data and structural context.
T74A (p.Thr74Ala) variant details
- p.Thr74Ala
- TOPMed rs1468059462
- gnomAD rs1468059462
- Missense
- Variant Prioritization Score for Impact Estimate 0.288
- REVEL 0.13
- MetaLR 0.12
- MetaSVM -0.86
- CADD 24.40
- PolyPhen-2 0.47
- SIFT 0.20
- Most common in the Non-Finnish European population (allele frequency 9.9e-07)
- Structural context available