P4R (p.Pro4Arg) variant of APOB (Apolipoprotein B-100)
P4R (p.Pro4Arg) in APOB (Apolipoprotein B-100) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data and structural context.
P4R (p.Pro4Arg) variant details
- p.Pro4Arg
- TOPMed rs1270559010
- gnomAD rs1270559010
- Missense
- Variant Prioritization Score for Impact Estimate 0.116
- REVEL 0.03
- MetaLR 0.01
- MetaSVM -0.97
- CADD 10.50
- PolyPhen-2 0.01
- SIFT 0.25
- Most common in the Ashkenazi Jewish population (allele frequency 5.1e-05)
- Structural context available